Acute PancreatitisEmergency

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Epigastric pain → back, N/V; gallstones / alcohol

ABCDE

IV access, moderately aggressive LR fluids (~1.5 mL/kg/h after bolus if hypovolemic); analgesia; O₂; monitor for organ failure; catheter.

Calculators:
  1. Confirm: Lipase (>3× ULN); CT for complications/severity
  2. Treat: Moderately aggressive LR (10 mL/kg bolus if hypovolemic, then ~1.5 mL/kg/h; reassess within 6 h and at 24–48 h — do not continue aggressive hydration beyond 48 h) + analgesia + early oral feeding (low-fat solids within 24–48 h in mild AP; NPO only for ileus/severe nausea; NG enteral over parenteral in severe AP)
  3. Gallstone + cholangitis → ERCP; cholecystectomy same admission

Order set

  • Lipase
  • FBC, U&E, Ca, glucose, LFTs
  • Moderately aggressive LR ~1.5 mL/kg/h (NOT 30 mL/kg)
  • USS (gallstones)
  • CT only if diagnosis unclear or no improvement at 48–72 h (not routine on admission)
  • Rectal indomethacin (± PD stent) for post-ERCP pancreatitis prophylaxis

Escalate / ICU

  • Persistent SIRS / organ failure >48 h
  • Hypoxia, oliguria, hypotension
  • High-volume resuscitation → HDU/ICU

Criteria

AdmitAll acute pancreatitis
ICUPersistent organ failure, severe SIRS, necrosis
IntubateARDS / respiratory failure
VasopressorsDistributive shock despite fluids
DialysisAKI with AEIOU
DischargePain controlled, eating, organ failure resolved, cause addressed

Never

  • Give prophylactic antibiotics unless infected necrosis
  • Early (<72 h) ERCP for biliary pancreatitis WITHOUT cholangitis — medical therapy first (ACG 2024)
Clinical detail — differentials, red flags, pitfalls, disposition
Red flags
  • Persistent SIRS/organ failure
  • Hypocalcaemia
  • Necrosis
Differentials
  • Perforated ulcer
  • Cholangitis
  • Mesenteric ischaemia
  • AAA
Common mistakes
  • Prophylactic antibiotics
  • Under-resuscitation
  • Delaying feeding
Disposition & follow-up

Severity scoring; HDU/ICU if organ failure; ERCP if cholangitis.

Discharge package
MedicationsAnalgesia; treat cause
Follow-upCholecystectomy if gallstones; alcohol support
LifestyleAlcohol cessation; low-fat diet initially
Warning symptomsSevere pain, vomiting, fever, jaundice
💊 Treatment detail — doses & preparation
Lactated Ringer's / Plasma-Lytebalanced crystalloid
DoseAcute pancreatitis: moderately aggressive — 10 mL/kg bolus if hypovolemic, then ~1.5 mL/kg/h; reassess at 6 h and 24–48 h; do NOT continue aggressive hydration beyond 48 h (fluid overload/respiratory failure — WATERFALL; ACG 2024)
Preparation500/1000 mL bags; contains K⁺ 4–5 mmol/L — still safe in most hyperK resuscitation
MonitorPerfusion (cap refill, urine, lactate) vs pulmonary oedema every aliquot
Morphineopioid analgesic
Dose2.5–10 mg IV q1–2 h PRN; PCA 1 mg bolus, 5–10 min lockout
Preparation10 mg/mL ampoule — dilute to 1 mg/mL for titration
MonitorRR, sedation, constipation; histamine release (hypotension/itch)
Ondansetron5-HT3 antiemetic
Dose4–8 mg IV/PO q8h PRN
Preparation4 mg/2 mL ampoule slow IV; ODT/tablets 4/8 mg
MonitorQT prolongation, constipation; headache
Antibiotics (selective)only if infected
DoseMeropenem 1 g q8h only for confirmed infected necrosis/cholangitis
PreparationPer culture
MonitorERCP within 24 h if cholangitis; infected necrosis → step-up approach, delay intervention >4 wk (against FNA)
📖 ACG 2024 Acute PancreatitisReviewed July 2026

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